Intrinsic and environmental factors in intrahepatic cholangiocarcinoma development
نویسندگان
چکیده
منابع مشابه
Intrahepatic cholangiocarcinoma and encephalomalacia in a budgerigar (Melopsittacus undulatus)
Encephalomalacia is softening or loss of brain tissue following cerebral infarction; cerebral ischemia infection, craniocerebral trauma or other injuries. Cholangiocarcinomas are malignant neoplasms of biliary epithelium, which usually arise from the intrahepatic ducts. A budgerigar was presented with a history of ataxia, decreased activity, neck weakness and weight loss. Supportive care was at...
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: In this short commentary, we discuss the most important risk factors for liver cancer. One of the most striking risks is infection with hepatitis B and C viruses, leading to chronic hepatitis, which may later develop into hepatocellular carcinoma (HCC). The use of alcohol may lead to cirrhosis, which is scarring the liver, is associated with 30 a more increase in HCC and 10-20 times more incr...
متن کاملGenetic profiling of intrahepatic cholangiocarcinoma and its clinical implication in targeted therapy.
Intrahepatic cholangiocarcinoma (iCCA) is a treatment-refractory primary liver cancer with an increasing incidence and mortality worldwide in recent years. Lack of a stereotyped genetic signature and limited understanding of genomic landscape make the development of effective targeted therapies challenging. Recent application of advanced technologies such as next-generation sequencing (NGS) has...
متن کاملAnalysis of p53 mutations for a mutational signature in human intrahepatic cholangiocarcinoma.
Cholangiocarcinoma development may be related to cholangiocyte DNA damage from genotoxic compounds in bile. We have previously shown that human biliary tissue is exposed to genotoxic agents, as evidenced by the presence of DNA adducts. Establishing the presence of a 'mutational signature' in tumour suppressor genes from tumour tissue provides a means of linking cause and effect in human cancer....
متن کاملThe clinical presentation and prognostic factors for intrahepatic and extrahepatic cholangiocarcinoma in a tertiary care centre.
BACKGROUND The incidence of cholangiocarcinoma is rising. Accurate predictors of survival at diagnosis are not well defined. AIM To clarify the clinical presentation and prognostic factors of intrahepatic cholangiocarcinoma and extrahepatic cholangiocarcinoma in a contemporary cohort of patients. METHODS Records for consecutive patients at the University of Michigan hospital diagnosed with ...
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عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2017